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Together, these processes create a toxic environment that progressively destroys motor neurons in ALS

This localized action is one of its most unique and appealing features, contributing to its minimal systemic side effects and high tolerability

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The MITF (microphthalmia-associated transcription factor) pathway is simultaneously upregulated downstream of PKA/CREB activation, serving as the master transcriptional regulator that coordinates the entire melanogenic enzyme cascade, and this cAMP-PKA-CREB-MITF axis represents the canonical signaling pathway measured in Melanotan II potency assays