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A comprehensive analysis by Tani et al., involving 216 pregnancies, found that while initiating low-dose aspirin did not significantly alter overall complication rates, it showed promise in potentially lowering the frequency of pre-eclampsia ( Selective use allowed during pregnancy Nonsteroidal anti-inflammatory drugs NSAIDs pose considerations during pregnancy, with evidence showing no link to congenital anomalies ( The FDA recommends the lowest NSAID dose between 20 and 30 weeks, with avoidance after 30 weeks to prevent complications, including premature closure of the ductus arteriosus ( Generally, NSAIDs, including Cox-1 and Cox-2 inhibitors, are discouraged in the third trimester due to heightened risks of adverse outcomes like ductus arteriosus closure

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