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Sensitivity analyses confirmed that the cardioprotective effect of GLP-1RAs is largely independent of glycaemic status, suggesting a direct cardiovascular benefit in patients with diabetes

G4 (G + B): similar to G2 and additionally received GA in drinking water at a concentration of 15% w/v and betaine (suspended in 0.9% saline at an oral dose of 200 mg/kg/day)

IGF-1 is synthesized and released from the liver along with some other tissue such as muscle, heart, adipose tissue, brain, and pancreatic -cell [41]

It also heightens the risk of several cancers, including colorectal, post-menopausal breast, uterine, esophageal, kidney and pancreatic cancers (WHO 2024