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However, the role of Parkin in APAP hepatotoxicity is uncertain as acute Parkin knockdown exacerbates APAP-mediated liver injury while chronic deletion using knockout mice results in resistance to APAP hepatotoxicity, most likely due to compensatory mechanisms that remain to be further characterized (Williams et al., 2015)

Nevertheless, the MR-Egger intercept showed no evidence of directional pleiotropy and the MR estimates from additional sensitivity analyses were consistent with the null finding, meaning that considerable bias due to pleiotropy is unlikely

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Padayatty SJ, Katz A, Wang Y, Eck P, Kwon O, Lee JH, Chen S, Corpe C, Dutta A, Dutta SK, Levine M