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The evolution from single to triple agonism The trajectory of incretin-based obesity pharmacotherapy shows a clear pattern of increasing complexity and efficacy: First generation (single agonist): Liraglutide (Saxenda) and semaglutide (Wegovy) target GLP-1 only

However, beyond the initial 3 to 6 month window, GLP-1 users typically experienced either continued weight loss, gradual plateau or partial regain as visualized in Figure 2