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Native IGF-1 exists as an FDA-approved human drug: recombinant human IGF-1, marketed as mecasermin (brand name Increlex), is approved for the treatment of growth failure in children with severe primary IGF-1 deficiency and in patients who have developed neutralizing antibodies to growth hormone

Semaglutide showed a lower risk of the secondary composite endpoint of heart failure hospitalization or urgent heart failure visit compared to sitagliptin in the expanded populations (HR 0.61, 95% CI 0.57 to 0.66)

Zofran can be taken as needed to help reduce nausea associated with GLP-1 treatment