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They include oral lubiprostone at a dose of 24 g every 12 hours or oral linaclotide at a dose of 145 g every 24 hours

Neurogastroenterology Motil 21(6):609e22 Hellstrm PM, Nslund E, Edholm T, Schmidt PT, Kristensen J, Theodorsson E, Efendic S (2008) GLP-1 suppresses Gastrointestinal motility and inhibits the migrating motor complex in healthy subjects and patients with irritable bowel syndrome