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[DOI] [PMC free article] [PubMed] [Google Scholar] 109.Braun RP, Baran R, Le Gal FA, Dalle S, Ronger S, Pandolfi R, Gaide O, French LE, Laugier P, Saurat JH, et al

Dropout was higher in the 12 mg arm than in the 9 mg arm, reinforcing a pattern already visible in Phase 2: the marginal efficacy gain from pushing to 12 mg comes at real tolerability cost

Oral administration of Dihexa achieves 4060% bioavailability with slower absorption kinetics compared to subcutaneous injection, potentially reducing the need for daily dosing due to sustained plasma concentrations

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