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Studies have shown that the use of antioxidants in PCOS therapy improves parameters describing the ratio of reactive nitrogen and oxygen species synthesis to antioxidant mechanisms, reduces the overall concentration of androgens in the body, and improves the physiological environment of the ovaries

However, some smaller molecules like retinoids and Vitamin C can penetrate deep into the live cells of the spinous layer, helping to stimulate cell turnover and providing antioxidant support

Trial investigators and participants were unaware of patients' allocation into groups during the trial

The contribution of these metabolites was only detectable when cells were cultured under physiological conditions