2nd week on semaglutide 7·2 mg was modestly superior to placebo and 2·4 mg (#wegovy) for #WeightLoss in adults with obesity, while retaining a favourable risk–benefit profile. We recently had the lead author the We are all anxiously awaiting

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Falcicchia C, Tozzi F, Arancio O, Watterson DM, Origlia N (2020) Involvement of p38 MAPK in synaptic function and dysfunction

The most common side effects of tirzepatide are gastrointestinal: Nausea: Reported by 12-33% of participants depending on dose (most common early in treatment) Diarrhea: 12-21% of participants Constipation: 6-11% of participants Vomiting: 5-13% of participants Decreased appetite: Expected therapeutic effect but can be uncomfortable These side effects are typically most intense during the first few weeks at each new dose level and tend to improve as the body adjusts