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In an attempt to curb GLP-1 prescriptions for weight loss and control rising costs, commercial plans have increased GLP-1 prior authorization requirements (e.g., step therapy)

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The GLP-1R is expressed in many tissues, including pancreatic islets, the central nervous system, lung, kidney, heart, intestine, and also on immune cells (49, 50), underlining the numerous roles for GLP-1-signaling beyond blood glucose control