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They have a profound effect on lowering proteinuria by lowering systemic blood pressure while having a direct action on the kidney microcirculation and reducing glomerular hypertension and hyperfiltration

Concerns include early treatment adjustment effects, individual sensitivity, and overlapping metabolic or psychological factors

Furthermore, numerous research studies have shown that long-term blockade of GLP-1R signaling by GLP-1R antagonist exenatide- (39) enhances SBP but doesnt affect DBP in normotensive and hypertensive rats, suggesting the relatively weak correlation between GLP-1 and DBP (99)

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