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A 2023 meta-analysis in The Lancet Diabetes & Endocrinology covering over 60,000 patients across GLP-1 receptor agonist trials found no statistically significant increase in acute pancreatitis risk (OR 1.02

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Among explanations for the absence of effect of long-term L-arginine administration in some clinical trials, oxidative depletion of BH 4 can result in eNOS uncoupling even with sufficient L-arginine supply (Xiong et al., 2014