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A medical review may help if you have an autoimmune disease and also deal with: Weight gain High blood pressure Type 2 diabetes Family history of heart disease Chest discomfort Shortness of breath Swelling in the legs History of blood clots Low activity due to pain or fatigue A primary care doctor can review your risk factors and decide whether you need labs, medication changes, lifestyle guidance, or specialist support

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Paradoxically, this increase has been associated with improved all-cause mortality as well as cardiovascular mortality, according to a post hoc analysis of the PROactive trial (259)