tirzepatide liver disease Challenging the Dogma: Reversal of End-Stage Fibrosis with in MASH Cirrhosis Mechanisms of benefits and risks

Varghese T, Dasgupta S, Anand G, Rejish Kumar VJ, Sahu NP, Pal AK, Puthiyottil M

Dietary Factors: Deficiencies in certain nutrients, such as vitamin B6, folate, and magnesium, can impair neurotransmitter synthesis

Important cofactors throughout Phase 2 include B vitamins, especially methylated versions of folate and B12, trace minerals such as iron, manganese, and molybdenum, amino acids like choline, cysteine, methionine, taurine, and others, like magnesium and vitamin C

Five trials had the glycaemic efficacy assessment as the primary objective, while one trial had cardiovascular outcome as the primary objective