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After the initial discoveries about GLP-1, researchers realized that there was a significant obstacle to its therapeutic use: the hormone was rapidly metabolized, lasting only a few minutes in the blood

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Recently, two randomized controlled trials (RCTs) demonstrated that tirzepatide, a dual GLP-1/GIP receptor agonists, reduced the AHI and hypoxic burden, and improved sleep-related patient-reported outcomes among individuals with moderate-to-severe OSA [24]

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