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These technologies may accelerate the discovery of novel therapeutic targets and the development of personalized regimens, serving as critical cutting-edge tools to advance autophagy-ferroptosis-targeted therapy from basic research to clinical translation

A marked depletion of beneficial taxa was identified, including a significant reduction in Ligilactobacillusa probiotic genus important for mucosal immunityas well as a pronounced decrease in Butyrivibrio, a key butyrate producer essential for gut barrier integrity, and a substantial decline in [Eubacterium]_siraeum_group, which is involved in SCFA production

A thermistor probe, inserted 56 cm into the rectum to allow regular recording of BT, was connected to a telethermometer (Yellow Springs Instruments) was taped to the tail

In the suppressor mutants, reduced Trx is not required for survival, but both GSH and Grx1 are