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Mathieu C, Dandona P, Gillard P et al (2018) Efficacy and safety of dapagliflozin in patients with inadequately controlled type 1 diabetes (the DEPICT-2 Study): 24-week results from a randomized controlled trial

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During mealtime, the network presented in this study driven by OB GLP-1R may contribute to a decrease in SNS activity, and thus participate in the increase of glucose-induced insulin secretion, in concert with systemic GLP-1 and the GLP-1 dependent neuronal circuitry of the brainstem and hypothalamus recruited under normal physiological circumstances