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Experimental Setting and study population This randomized, double-blind, multicenter, placebo-controlled clinical trial was conducted in two hospitals in Iran including Masih Daneshvari hospital, the national referral center of tuberculosis and lung diseases affiliated to Shahid Beheshti University of Medical Sciences, and Al-Zahra hospital complex affiliated to Isfahan University of Medical Sciences (IUMS), the largest tertiary care medical center and a referral infectious diseases ward in the region, from June 2016 to September 2018