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Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia

The mechanismGLP-1 receptor activation affecting pancreatic and gastrointestinal developmentraises theoretical concerns during critical fetal windows

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Accordingly, the effectiveness of NHPN-1010 in treating cochlear neuropathy in the absence of hair cell loss likely reflects the regeneration of missing peripheral terminals and the formation of new synaptic connections, rather than simply enhancing recovery of damaged neuronal terminals