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Unlike retinoids, which can cause chronic sensitivity and a plateau effect with long-term use, GHK-Cu's gene modulation data suggests ongoing regenerative signaling with sustained application

Endocrine 48(3):756775

Dong J, Xiao D, Zhao Z, Ren P, Li C, Hu Y, Shi J, Su H, Wang L, Liu H, Li B, Gao P, Qing G (2017) Epigenetic silencing of microRNA-137 enhances ASCT2 expression and tumor glutamine metabolism

Since an IGF-1R construct, in which the tyrosine at position 1136 was replaced by a phenylalanine, also led to a strong inhibition of phosphorylated Akt in transfected cells, it was suggested that this mechanism may be responsible for the apoptotic effect of PPP (Vasilcanu et al, 2004)