In the early phases of neuroinflammation, gene expression tends to favor proliferation, whereas in later stages, immune-response genes become predominant, accompanied by the downregulation of homeostatic genes responsible for structural integrity, cell adhesion, and receptor function [31, 42, 43]
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Abbreviations CHO: Chinese hamster ovary DPP-4: Dipeptidyl peptidase-4 GLP-1: Glucagon-like peptide-1 HTRF: Homogenous time-resolved fluorescence MMTT: Mixed-meal tolerance test PCSK9: Proprotein convertase subtilisin/kexin type 9 TEAE: Treatment-emergent adverse event References International Diabetes Federation (2017) IDF Diabetes atlas - 8th edition
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