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The mechanism involves modulation of dopamine and serotonin systems alongside promotion of nerve growth factor

The actin-binding region itself has been linked to vascular activity: a 2003 study in the FASEB Journal reported that the site promoting actin interaction is also associated with angiogenic activity in experimental models

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Serine 408 phosphorylation is a molecular switch that regulates structure and function of the occludin -helical bundle