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HGF: hepatocyte growth factor The brain HGF/Met system appears to be designed to respond to injury as seen in stroke and neuro-degenerative diseases by facilitating synaptic plasticity and neurogenesis

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Bone mineral density and lean mass gains were observed in aged rat models, consistent with expected GH/IGF-1 axis activity

These pathways not only preserve proteome integrity but also offer powerful therapeutic opportunities, as demonstrated by the emergence of proteasome inhibitors, autophagy modulators, and molecular chaperone-targeting agents in clinical medicine (Tables 1 and 2)