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According to a study published in JAMA, nearly 40% of GLP-1 prescriptions for diabetes are now being used off-label for weight loss or other unapproved conditions

Risk of cardiovascular and hemolytic disease in G6PD-deficient patients

Future research assessing the effect of prolonged fasting on obesity-related gene expression may help elucidate which patients would benefit from prolonged fasting

Indeed, in the first report that demonstrated a significant role of ceramide in erythrocyte death pathways, it has been ruled out that the elevated ceramide levels originate from the biosynthetic pathway [122]