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The results of the current randomized, double-blind, placebo-controlled clinical trial demonstrated that oral administration of l-ARG at the dose of 6 g/day for 3 months significantly improved penile erectile function assessed by IIEF-6 score and PSV evaluated at dynamic PDU in 50 male patients with vasculogenic ED, compared to 45 placebo-treated patients

The secretion of inflammatory cytokines, such as tumor necrosis factor (TNF)-a, would lead to neuroinflammation and migraine episodes by increasing the cellular permeability and interactions

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Not because Ozempic itself was particularly significant as a self-injected drug (it has been around since 2017), but because the cultural moment around 2022 onwards turned a once-weekly peptide injection into a celebrity-endorsed, mass-market behaviour