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Once activated, Akt, one of the main downstream targets of mTORC2 [296], induces inhibitory phosphorylation of the positive regulators of autophagy Beclin-1 [297], forkhead box O3 (FoxO3) [257], and glial fibrillary acidic protein (GFAP) [298]
The confusion was due to the fact that riboflavin (B 2 ) deficiency causes stomatitis symptoms similar to those seen in pellagra, but without the widespread peripheral skin lesions
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