This process requires the transport of TML across the inner mitochondrial membrane (IMM), which is impermeable to metabolites
Alternative Routes of Administration & the First-Pass Effect There are several reasons for different routes of administration used in clinical medicine ( Table 33 )for convenience (eg, oral), to maximize concentration at the site of action and minimize it elsewhere (eg, topical), to prolong the duration of drug absorption (eg, transdermal), or to avoid the first-pass effect (sublingual or rectal)
Additional Observations Demographic data (e.g., average age, gender distribution, and ethnicity) were provided for cohorts 6, 7, and 8
To maintain that and be very vigilant about falling back into old habits