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Avoid inflammatory foods that may worsen gut permeability

The pathophysiology of DOX-induced POI is complex, but numerous factors have been proposed to be linked to the onset and development of ovarian dysfunction, including free radical-mediated lipid peroxidation, oxidative stress, mitochondrial malfunction, increased proinflammatory release of cytokines, and granulosa cell apoptosis 12,13,14

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The oral route is non-invasive and convenient, allowing for relatively rapid absorption and distribution of the active ingredients in herbal remedies, thus providing adequate therapeutic effects (98)