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2 Association mechanisms between intestinal dysbiosis, SCFA reduction, and renal fibrosis in DKD 2.1 Gut dysbiosis and SCFA depletion in DKD Intestinal dysbiosis, characterized by reduced SCFA-producing bacteria and decreased microbial diversity, emerges as a hallmark feature of DKD pathogenesis, directly contributing to renal fibrosis through diminished SCFA production and subsequent activation of inflammatory pathways

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