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Kupffer cells, the resident macrophages of the liver, and monocyte-derived macrophages have both been implicated as cells that both contribute to the injury and are critical for regeneration

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The SELECT trial showed a 20% MACE reduction

331,332 Multiple PD-associated genes, such as LRRK2, SYNJ1, DNAJC6, and DNAJC13, regulate synaptic endocytosis, autophagy, lysosomal function, and endolysosomal trafficking, underscoring the intertwined regulation of vesicular dynamics and proteostasis in dopaminergic neurons