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Braca highlighted that these patients had been selected because they had not responded to other migraine drugs, such as antibodies that target calcitonin gene-related peptide (CGRP), a molecule released in the brain during a migraine
Broad Institute
More recent preclinical studies have demonstrated that the central genetic activation of GIPR + neurons in the hypothalamus may also reduce food intake and promote weight loss [65], findings consistent with the peripheral administration of long-acting degradation-resistant GIPR agonists in mice with diet-induced obesity [66]
Additionally, the RCTs primarily involved EX interventions, which may further reduce GOAT activity by redistributing blood flow from the splanchnic region to active muscles [171], although long-term effect remains unclear
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