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Last reviewed: June 19, 2026 Last updated: June 19, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

doi: 10.1007/s11033-025-10553-9

Effect of lipophilicity on drug distribution and elimination: influence of obesity

In addition to changes in the saturation of ePLs and TAGs, giredestrant treatment also resulted in a global decrease in diacylglycerols (DAGs) and hexosylceramide (HCER), and an elevation of sphingomyelin (SM) (Supplementary Fig