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In 2021, approximately 537 million adults worldwide were diagnosed with diabetes, and this number is projected to rise to 783 million by 2045 ( Beyond its metabolic consequences, cigarette smoking is causally associated with chronic obstructive pulmonary disease, interstitial lung disease ( Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used in the treatment of T2DM due to their glucose-lowering efficacy and beneficial effects on body weight ( A recent large-scale real-world observational study using target trial emulation reported an association between semaglutide use and a reduced risk of tobacco use disorder in patients with T2DM ( Therefore, this randomized controlled trial aims to investigate the effects of GLP-RA on nicotine dependence and smoking-related outcomes in patients with T2DM, and to explore potential neural mechanisms using functional magnetic resonance imaging (fMRI)

In hepatocellular carcinoma models, caudatin administration correlated with significant reductions in VEGF expression and tumor microvessel density (Table 1, Row 13)

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