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Melanotan-2 remains the only available pharmacological tool allowing the simultaneous study of the relative contributions of the four MCR receptors using selective antagonism protocols (HS024 for MC4R, JNJ-10229570 for MC3R, etc.)

As clinicians continue to address the growing overlap between obesity, diabetes, and chronic pain, GLP-1 therapies are attracting attention as a potentially broader metabolic intervention

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Media used for microcarriers were supplemented with poloxamer 188 (Cat#: P5556, Sigma-Aldrich, St