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Furthermore, both SM and exenatide selectively activated p38 MAPK phosphorylation in the spinal cord, providing additional evidence that SM exerts its anti-allodynic effects by targeting spinal GLP-1R and promoting microglial -endorphin synthesis via the p38 MAPK signaling cascade [72]

The ELAD trial (Evaluating the Effects of the Novel GLP-1 Analogue Liraglutide in Alzheimers Disease) was a Phase 2b randomized, double-blind, placebo-controlled study in ~204 patients with mild AD

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