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The finding that the increase in GLP-1 was only evident after intraduodenal glucose infusion and was minimal when metformin was administered immediately before intraduodenal glucose suggests that the effect of metformin on GLP-1 is primarily related to modulation of the glucosegut interaction [8, 34]
It is important to note some discrepancies that could affect interpretations of the role of GLP-1
This phenomenon arises from the characteristic leaky vasculature and impaired lymphatic drainage present in many solid tumors [101, 102]
USA 100 , 1220112206 (2003)
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