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Weak opioids Weak opioids are prescribed frequently, either alone or in combination with other analgesics, for a wide variety of painful disorders

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their electrophilic chemistry and rapid reactivity limit systemic use at present but they define a potent downstream entry point for ferroptosis (85, 86)

This leads to increased intestinal permeability and the accumulation of microbial metabolites (including lipopolysaccharide), which intensify the inflammatory response in the intestinal mucosa