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After an 8-week 800 kcal/day low-calorie diet that produced a mean 13.1 kg weight loss, 195 adults with obesity (BMI 3243, no diabetes) were randomized for one year to one of four arms: placebo, structured exercise, liraglutide 3 mg/day, or exercise plus liraglutide

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By providing exogenous pyridoxine that is readily converted to PLP, the injection corrects the coenzyme deficiency and reactivates these metabolic pathways