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p = 0.021] in the semaglutide group versus placebo group were observed ( post hoc analysis may, in part, reflect the modest weight loss achieved over a relatively short intervention period, particularly when compared with outcomes observed in larger, longer-term trials

Therefore, further in-depth animal and clinical studies on the mechanisms by which irisin alleviates depression could facilitate the development and testing of new treatments, reduce the incidence of depression, and provide benefits for patients unable to exercise due to physical limitations

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Common concerns include: *In a 68- and 72-week clinical trial studying Wegovy (2.4 mg) and Zepbound (15 mg) in patients without diabetes and with BMI 30, or BMI 27 with a weight-related condition, the average weight loss was 15% and 20%, when paired with diet and exercise changes (compared to 2.4% and 3.1%, respectively, with diet and exercise alone)