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Genetic determinants of response to warfarin during initial anticoagulation

PT-141 Receptor Selectivity PT-141 shows meaningfully greater selectivity for MC3R and MC4R compared to MC1R and MC5R: MC4R activity: Strong agonist activity MC3R activity: Strong agonist activity MC1R activity: Reduced compared to Melanotan 2 MC5R activity: Reduced compared to Melanotan 2 This selectivity profile means research designs using PT-141 can more confidently attribute observed effects to MC3R and MC4R mechanisms rather than other melanocortin receptor activity

Bailey J, Barrett A, Coucha M, Abdelsaid MA

It is not, however, approved by the FDA in the United States