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Tuft cells express succinate receptor 1 on their surface which detects the presence of this in SCFA in the gut lumen stimulating downstream signalling pathways and leading to a type-2 IR (Nadjsombati et al

While CYP enzymes are responsible for activation, enzymes such as glutathione S-transferase (GST) contribute to the detoxification of reactive metabolites, particularly acrolein (Alnasser, 2025)

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Yes for most healthy adults