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Energy can be tricky to define and study, but we can look at data on creatines impact on fatigue in specific circumstances: Older adults were more resilient to physical fatigue after 14 days of high-volume creatine supplementation

When you reduce your calorie intake, a cascade of metabolic changes affects your fluid balance, from falling insulin levels prompting the kidneys to excrete more sodium and water, to the release of water stored alongside glycogen

Sleep disorders, particularly obstructive sleep apnea, cause daytime fatigue that may overshadow concurrent iron deficiency

Antihistamines are essentially putting up an umbrella