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Review all concurrent medications for appetite-stimulating effects

Consider Alternative Strategies For some patients, the following approaches may be discussed: Extended treatment duration : Continuing Wegovy beyond the initial assessment period, within the 2-year maximum treatment duration Intensified lifestyle intervention : Additional support within specialist weight management services Alternative medications : If Wegovy proves ineffective, other UK-licensed options such as orlistat or naltrexone/bupropion may be considered (availability varies by local NHS commissioning policies) Bariatric surgery referral : For individuals with BMI 40 kg/m (or 35 kg/m with comorbidities) who have not responded to non-surgical approaches

Discussion Semaglutide did not reduce the bioavailability of ethinylestradiol or levonorgestrel

In addition to this, a 10% total weight reduction was achieved by 5-38% of Semaglutide participants, compared to just 0-8% with those taking Liraglutide injections