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Baker ZG, Dellapina M, Gustavson AM, et al

What they found: Dose-dependent stimulation of type II collagen (up to 2.5 baseline at 100 nM) Stimulation of aggrecan (up to 1.8 baseline) Inhibition of MMP-13 by ~40 % Partial protection against IL-1-induced matrix degradation Why it matters: It opened a completely new research area for AOD-9604 beyond lipolysis

The mechanism of HFD-induced hyperglycemia was therefore investigated in Insr P1195L/ + mice

Reduction of total fluid volume occurs through the inhibition of sodium reabsorption in the distal tubules, which causes increased excretion of sodium, water, potassium, and hydrogen