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Solvent reflux extraction, typically performed with organic solvents under controlled temperature, achieves higher yields through relatively mild processing

The high fat diabetic mice and experimental design Male C57BL/6 J mice (Su Pu Si Biotechnology, Co., Ltd., Suzhou, Jiangsu, China) were randomly assigned to four groups at 4 weeks of age (n = 812/group): (1) HF diabetic control mice were fed HFD (D12492 Research Diets, New Brunswick, NJ, in which 60% of calories are from fat) with sterile water by gavage daily, (2) HF diabetic CB mice were fed HFD with CB0313.1 by gavage at 2.5 10 8 CFU/kg/day (suspended in sterile water), (3) HF diabetic NaB mice were fed HFD with sodium butyrate (NaB, Sigma 303410, St

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It works by neutralizing free radicals and altering the production of melanin, the pigment responsible for skin color