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Adjustment Phase After the initial phase, the dose is usually increased to 5 mg once a week for 4 weeks, followed by a second increase to 7.5 mg once a week

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Insulin secretion and beta cell preservation Many in vitro and preclinical studies have examined agents that enhance insulin secretion, including agents that generate ATP, inhibit K + -ATP channels, raise cytosolic calcium, activate muscarinic or imidazoline receptors, suppress 2-adrenergic receptors, inhibit phosphodiesterases to increase cAMP, stimulate phospholipases or modulate various intracellular regulators of insulin exocytosis