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The role of ABC transporters in clinical practice

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[21] Within cells, cyanocobalamin is converted to methylcobalamin and 5- deoxyadenosylcobalamin, coenzymes that participate respectively in homocysteine remethylation to methionine and in the isomerization of methylmalonyl-CoA to succinyl CoA, reactions essential for DNA synthesis, erythropoiesis, and myelin maintenance

Given the beneficial effects of several precursors and inhibitors summarized above, these strategies may be promising for finding a therapeutic strategy for AD, either as lead molecules or in combination approaches with other classes of molecules or drugs, with several studies having been launched at the clinical level