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When the first GLP-1 drugs came on the scene two decades ago, they were greeted by the medical community as a major step forward in the treatment of diabetes
Positron emission tomography to assess drug occupancy at peripheral and central incretin receptors Amina Khalil, a Irina Velikyan, a , b , c Mengfei Xiong, a Martin Bossart, d Michael Wagner, e and Olof Eriksson a , f , a Science for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden b PET-Centre, Centre for Medical Imaging, Akademiska Sjukhuset, Uppsala, Sweden c Department of Surgical Sciences, Radiology and Molecular Imaging, Uppsala University, Uppsala, Sweden d Integrated Drug Design, Synthetic Medicinal Modalities, Sano, Frankfurt, Germany e Dewpoint Therapeutics, Frankfurt, Germany f Antaros Tracer AB, Uppsala, Sweden Summary Background Incretin mimetics, especially dual/triple agonists, are effective for type 2 diabetes and obesity, though mechanisms remain unclear
Start your intake How GLP-1 Therapy Affects Thyroid Hormone Metabolism GLP-1 medications slow gastric emptying, which can temporarily reduce levothyroxine absorption if taken simultaneously
