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Furthermore, through epigenetic mechanismsspecifically the acetylation of histonesALCAR can upregulate specific receptors like metabotropic glutamate 2 (mGlu2), a pathway that stimulates neurogenesis, enhances synaptic plasticity, and has been strongly tied to the compound's clinical antidepressant effects

Importantly, by regulating cellular hydroperoxides (and RNS), GPx-1 may protect against oxidative stress, but, in excess, GPx-1 may also have deleterious effects due to a lack of essential cellular oxidants (154, 251) that result in a reductive stress characterized by a lack of oxidants and/or excess reducing equivalents (297) (Fig

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